Chronic infections or the deleterious effect of venereal diseases such as syphilis, produce their worst effects in the larger stages of foetal life and may affect mental development. High blood pressure, diabetes and blood incompatibilities may affect foetal development. The increase in miscarriages and maternal or foetal death are directly related to the high blood pressure of the pregnant mother. Infants of diabetic mothers have a relatively high proportion of infant mortality and abnormalities, particularly of the respiratory and circulatory systems.
In addition, an incompatibility can occur between the blood types of the mother and child. Rh blood incompatibility is the most frequent and destructive. If the mother is Rh negative and the foetus has a Rh positive blood group from the sperm cell of the father, infant death can occur due to destruction of red blood corpuscles. This is because antibodies are produced in the blood of the Rh negative mother. These toxic antibodies are incompatible with the fetal blood causing probable death of the fetus unless the condition is diagnosed and precautions are taken.
Maternal sensitivity to Rh positive foetus antigens increases with successive pregnancies and although the first pregnancy might be normal, later ones are less likely to be so.